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Each vial contains 25 mg of medroxyprogesterone acetate and 5 mg Estradiol Cypionate.

Available in box of 20 vials @ 0.5ml.

The continuing search for birthcontrol techniques which would offer options to choose the best regimen suited for individual need would never end. After world wide acceptance of the pills, CYCLOGESTON is the next convenience of one monthly injection, the users still have their regular menses and the rapid return to fertility.

CYCLOGESTON is a monthly intramuscular injectable contraceptive consists of a mixture of a long acting progestogen and a long acting estrogen. The depot effect results from the slow absorption from the injection site.

Parenterally, medroxyprogesterone acetate is a long acting progestogen and a long acting progestational steroid. Medroxyprogesterone acetate administered parenterally to women with adequate endogenous estrogen transforms proliferative endometrium into secretory endometrium.

Medroxyprogesterone inhibits the secretion of pituitary gonadotropin which, in turn, prevents the follicular maturation and ovulation. The effects on the endometrium, the fallopian tubes and progestational changes in the cervical mucus, inhibits sperm penetration into uterus, thus increasing the difficulty of nidation.

The progestin alone had been shown to interfere with fertility when administered intramuscularly. However, complete disruption of the menstrual cycle ensued. The long acting estradiol was added in the formula to induce monthly uterine bleeding mimicking the normal menstrual pattern as closely as possible. CYCLOGESTON would have a psychological advantage by enabling most users to have a regular monthly cycle, ensuring free of pregnancy, a plus point that would improve the acceptability and compliance of the acceptors.

CYCLOGESTON is proved to be completely effective in preventing pregnancy bedides it is safe and well accepted. It is ideal for birthspacing in women who, for various reasons, cannot be relied upon to take oral contraceptives.

Copyright © 2008 by PT Usahatama Sentosa Mas